Seventh-ranked Bryan (29-4-1) posted a 6-1 victory in Game 1 on Thursday night behind Sean Weatherford's 13-strikeout five-hitter.
Game 3 will start 30 minutes after Game 2, if necessary.
The Bryan-Lufkin winner advances to face the Cedar Park-Tomball winner.
Cedar Park's Britt Robertshaw hurled a one-hit shutout in Thursday's 1-0 victory over Tomball 1-0 in their best-of-3 series.
Robertshaw faced the minimum 21 batters while striking out eight. Tomball's Luke Pluncheck had a two-out single to left in the second inning, but Robertshaw picked him off first. Tomball's David Rumsey limited the Timberwolves (23-13) to just three hits.
Cedar Park's run was unearned as Tomball (17-10) committed three errors
Game 2 was set for Friday in Tomball.
BRYAN 212 100 0 -- 6 8 0
LUFKIN 010 000 0 -- 1 5 2
Sean Weatherford and Collin Janssen; Marty Anderson, Marcus Drake, Luis DeJesus and Zach Marberry.
WP: Weatherford 9-1. LP: Anderson 5-6.
2B: Tyler Grygar, Geronimo Longoria, David McFarland.
3B: Krey Bratsen.
Records: Bryan 29-4-1, Lufkin 18-16