EUGENE, Ore. -- Jeremiah Masoli threw for 222 yards and a touchdown and ran for 164 more yards with another score and the No. 10 Oregon Ducks ran past No. 4 USC 47-20 for the Trojans' worst loss since 1997.
Redshirt freshman LaMichael James ran for 183 yards and a score as the Ducks (7-1, 5-0 Pacific-10) racked up 391 yards on the ground against the Trojans, who came into the game with the fifth-best rush defense in the nation, allowing an average of just 79.9 yards.
Oregon remained undefeated in the Pac-10, threatening USC's hold on the league championship for the past 7 years.
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No. 1 Florida 41, Georgia 17: JACKSONVILLE, Fla. -- Tim Tebow accounted for four touchdowns, A.J. Jones had two huge interceptions for top-ranked Florida.
The Gators (8-0, 6-0) extended their winning streak to 18 games and clinched the SEC East title.
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No. 5 Cincinnati 28, Syracuse 7: SYRACUSE, N.Y. -- Zach Collaros threw four TD passes to get the Bearcats within a win of the best start in school history.
Collaros hit Armon Binns on scoring passes of 81 and 13 yards, Kazeem Alli for 16 yards off a fake field goal, and Adrien Robinson for 4 yards for Cincinnati (8-0, 4-0 Big East).
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No. 6 Boise State 45, San Jose State 7: BOISE, Idaho -- Kellen Moore threw for 278 yards and three touchdowns and ran for another to get the Broncos their eighth straight win.
Boise State (8-0, 3-0 Western Athletic Conference) held the Spartans (1-6, 0-3) to 223 total yards and forced two turnovers that led to touchdowns.
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No. 7 Iowa 42, Indiana 24: IOWA CITY, Iowa -- Ricky Stanzi overcame a career-high five interceptions to throw two long touchdown passes in the fourth quarter.
Brandon Wegher had a career-high 118 yards rushing and three TDs for the Hawkeyes (9-0, 5-0 Big Ten), who scored 28 points in the fourth to stun the Hoosiers.
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No. 8 TCU 41, UNLV 0: FORT WORTH -- Andy Dalton threw three touchdown passes, Ed Wesley scored running and catching the ball and the TCU defense smothered UNLV to get its first shutout.
The eighth-ranked Horned Frogs (8-0, 4-0 Mountain West) probably did enough to stay in position to be this season's BCS buster.
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No. 9 LSU 42, Tulane 0: BATON ROUGE, La. -- Brandon LaFell caught two touchdown passes.
Charles Scott rushed for 112 yards and two touchdowns.
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No. 12 Penn State 34, Northwestern 13: EVANSTON, Ill. -- No. 12 Penn State shut out Northwestern in the second half and scored 3 fourth-quarter TDs.
Daryll Clark threw a 53-yard TD pass to Derek Moye and Evan Royster broke off a 69-yard scoring run to highlight the surge.
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No. 15 Houston 50, Southern Miss 43: HOUSTON -- Case Keenum threw for a career-high 559 yards and had five touchdowns, his last coming with 21 seconds remaining.
Keenum broke the tie with a 46-yard pass to Patrick Edwards. The Golden Eagles had a chance to tie it, but Martevious Young's heave was knocked down in the end zone.
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No. 17 Ohio St. 45, New Mexico St. 0: COLUMBUS, Ohio -- Dane Sanzenbacher caught two TD passes and Terrelle Pryor threw for one and ran for another.
Tempering the win was the possible loss of kicker Aaron Pettrey, who left with a leg injury.
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No. 18 Miami 28, Wake Forest 27: WINSTON-SALEM, N.C. -- Jacory Harris threw a 13-yard touchdown pass to Travis Benjamin with 1:08 left.
Harris threw for 330 yards and three touchdowns for the Hurricanes (6-2, 3-2 ACC), who trailed 27-14 going into the fourth quarter.
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No. 19 Utah 22, Wyoming 10: SALT LAKE CITY -- Utah freshman Jordan Wynn passed for 82 yards and a touchdown in his college debut, replacing starter Terrance Cain in the second half.
Eddie Wide tied a school record with his fifth straight 100-yard rushing game and added a late touchdown to seal the win for Utah (7-1, 4-0 Mountain West), which trailed 10-3 at halftime.
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Auburn 33, No. 24 Mississippi 20: AUBURN, Ala. -- Chris Todd passed for 212 yards, Ben Tate ran for 144 yards and Walt McFadden returned an interception for a touchdown.