A&M (12-1) built a 50-40 lead, but FSU (12-4) dominated thereafter as the Aggies missed 18 of their final 20 shots.
"Their matchup zone was good in limiting us to one shot in the last 10 minutes," A&M head coach Gary Blair said.
A&M senior guard Takia Starks, who had scored at least 20 points in three straight games, was held to six points on 3-of-18 shooting. Fellow senior Danielle Gant played all 40 minutes but was held to 10 points, hitting 4 of 10.
"My two All-Americans did not play like All-Americans," Blair said. "This was a good learning experience for us."
FSU's Tanae Davis-Cain scored 11 of her 13 points in the second half as the Seminoles shredded A&M's defense after intermission by hitting 15 of 23 field goals after missing 19 of 24 in the first half.
"The first 10 minutes of the second [half], we played really well, but in the last 10 minutes, our intensity went down," said A&M guard Tanisha Smith, who scored 17 points. "They kept going and were making their shots, while we were missing wide-open shots."
A&M made 7 of 32 field goals in the second half (21.9 percent), including only 1 of 11 3-pointers as the Aggies squandered a 17-point lead.
"I really thought at the beginning of the game we were putting ourselves in position to win," FSU head coach Sue Semrau said. "When we were down 10 at halftime and had only scored 19 points, it seemed pretty improbable."
The Aggies trailed early but played well late in the first half to take a 29-19 lead at the break.
"Florida State kept their composure," Blair said. "Sue did a great job of not panicking and not getting down on her kids."
Center Jacinta Monroe led FSU with 15 points, hitting 6 of 8 field goals. She also had a game-high nine rebounds.
A&M, which was gunning for a school-record 13th straight victory, also failed to post the first unbeaten non-conference season in school history.
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NOTES -- The Big 12 named Starks its player of the week after a pair of 20-point games last week. She had 24 points, five rebounds and five assists against New Mexico and 22 points, five rebounds and a career-high six steals against George Washington.