After going 8-0 in opening games, the league was just 2-6 in the second round. Kansas State, Oklahoma, Texas and Nebraska were eliminated Tuesday. Baylor and Iowa State lost Monday.
Texas A&M and Oklahoma State were the only Big 12 teams to advance to the round of 16.
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Connecticut 89, Texas 55: BRIDGEPORT, Conn. -- Maya Moore scored 24 points and the Huskies shot a blistering 60 percent from the field, handing the Longhorns their worst tournament loss ever.
Renee Montgomery added 17 points and Tina Charles had 15 for the Huskies, who routed Cornell 89-47 in the opening round.
Carla Cortijo scored 18 points and Earnesia Williams added 12 to lead the eighth-seeded Longhorns (22-13).
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Notre Dame 79, Oklahoma 75, OT: WEST LAFAYETTE, Ind. -- Charel Allen scored a career-high 35 points and made all the big plays to rally Notre Dame from a late-seven point deficit.
Allen hit 10 of 21 shots, all 12 free throws for the fifth-seeded Fighting Irish (25-8).
Courtney Paris, last year's national player of the year, finished with 24 points and 16 rebounds for fourth-seeded Oklahoma (22-9).
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Louisville 80, Kansas State 63: Angel McCoughtry scored 24 and the Cardinals advanced to the regional semifinals for the first time in 12 tries with an 80-63 victory Tuesday.
Ashley Sweat had 16 points and reserve Kelsey Nelson added 12 to lead Kansas State (22-10).
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Maryland 76, Nebraska 64: COLLEGE PARK, Md. -- Marissa Coleman and Kristi Toliver had 19 points apiece, Crystal Langhorne had 18 points and 12 rebounds, and the Terrapins held off Nebraska after blowing a 15-point lead.
Yvonne Turner scored a career-high 23 points for the Cornhuskers (21-12).
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North Carolina 80, Georgia 66: NORFOLK, Va. -- Rashanda McCants scored 23 point and North Carolina used a 20-0 run spanning the halves to thwart the Bulldogs.
Erlana Larkins added 18 points and 10 rebounds for the top-seeded Tar Heels (32-2).
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Old Dominion 88, Virginia 85, OT: NORFOLK, Va. -- Jazzmin Walters made a 3-pointer with 4.8 seconds left in overtime Tuesday night, and Tiffany Green blocked an attempt at a tying 3-pointer just before the buzzer, giving the Lady Monarchs a victory and a trip to the Greensboro Regional.
Fifth-seeded Old Dominion (31-4) fell behind 85-81 in overtime, but closed the game on a 7-0 run.
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Duke 67, Arizona State 59: COLLEGE PARK, Md. -- Chante Black scored a career-high 26 points and had 13 rebounds, and the third-seeded Blue Devils never trailed on their way to advancing to the round of 16 for the 11th consecutive season.
The Blue Devils (25-9) will next face No. 2 seed Texas A&M on Sunday in the Oklahoma City regional semifinals.
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Tennessee 78, Purdue 52: WEST LAFAYETTE, Ind. -- Two days after Pat Summitt publicly challenged her team to play harder, the Lady Vols responded with a rout of host Purdue.
Candace Parker had 24 points, eight rebounds and three blocks.